Version 5.4
| Homo sapiens Gene: MPST | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-6249.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | MPST | ||||||||||||||||||
| Gene Name | mercaptopyruvate sulfurtransferase | ||||||||||||||||||
| Synonyms | MST; TST2 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000128309 | ||||||||||||||||||
| Encoded Proteins |
mercaptopyruvate sulfurtransferase
mercaptopyruvate sulfurtransferase
mercaptopyruvate sulfurtransferase
mercaptopyruvate sulfurtransferase
mercaptopyruvate sulfurtransferase
mercaptopyruvate sulfurtransferase
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 22:37019635-37029822 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q12.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Sulfur metabolism pathway
Cysteine and methionine metabolism pathway
Sulfur relay system pathway
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| INOH |
Methionine Cysteine metabolism pathway
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| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P25325 | ||||||||||||||||||
| TrEMBL | Q2VEU0 Q2VEU1 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 4357 | ||||||||||||||||||
| UniGene | Hs.248267 | ||||||||||||||||||
| RefSeq | NM_001130517 NM_001013436 NM_021126 XM_005261610 | ||||||||||||||||||
| HUGO | HGNC:7223 | ||||||||||||||||||
| OMIM | 602496 | ||||||||||||||||||
| CCDS | CCDS13939 | ||||||||||||||||||
| HPRD | 11896 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AK055733 BC003508 BC016737 BC018717 BT019636 CH471095 CR456523 CR541712 DQ211531 DQ211532 DQ211533 X59434 Z73420 | ||||||||||||||||||
| GenPept | AAH03508 AAH16737 AAH18717 AAV38442 ABB16334 ABB16335 ABB16336 BAG51564 CAA42060 CAG30409 CAG46513 EAW60133 EAW60134 EAW60135 | ||||||||||||||||||
| RNA Seq Atlas | 4357 | ||||||||||||||||||