InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTF1A

Summary

InnateDB Gene

IDBG-62659.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTF1A

Gene Name

pancreas specific transcription factor, 1a

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000168267

Encoded Proteins

IDBP-62661

pancreas specific transcription factor, 1a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:23192327-23194252

Strand

Forward strand

Band

p12.2

Transcripts

ENST00000376504

ENSP00000365687

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009790	embryo development
GO:0009888	tissue development
GO:0010842	retina layer formation
GO:0021549	cerebellum development
GO:0030154	cell differentiation
GO:0030902	hindbrain development
GO:0031016	pancreas development
GO:0031017	exocrine pancreas development
GO:0031018	endocrine pancreas development
GO:0035881	amacrine cell differentiation
GO:0045165	cell fate commitment
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048384	retinoic acid receptor signaling pathway
GO:0048663	neuron fate commitment
GO:0048699	generation of neurons
GO:0060042	retina morphogenesis in camera-type eye
GO:0061074	regulation of neural retina development

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026735

View Gene Order

ENSBTAG00000047315

Not yet available

Pathways

NETPATH

REACTOME

REACT_13778

Regulation of gene expression in early pancreatic precursor cells pathway

REACT_111045

Developmental Biology pathway

REACT_13698

Regulation of beta-cell development pathway

KEGG

INOH

PID NCI

hes_heypathway

Notch-mediated HES/HEY network

Cross-References

SwissProt

Q7RTS3

TrEMBL

UniProt Splice Variant

Entrez Gene

256297

UniGene

Hs.351503

RefSeq

NM_178161

HUGO

HGNC:23734

OMIM

607194

CCDS

CCDS7143

HPRD

IMGT

EMBL

AF181999 AL139281 BK000272

GenPept

AAG09441 CAI12668 DAA01052

RNA Seq Atlas

256297