Version 5.4
Homo sapiens Gene: DEFB4B
Summary
InnateDB Gene IDBG-6283.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEFB4B
Gene Name defensin, beta 4B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177257
Encoded Proteins
IDBP-480680
defensin, beta 4B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25847963
Exposure to ambient air pollution particulate matter deregulates the ability of the human type II alveolar epithelial cells (A549) to express the antimicrobial peptides HBD-2 (DEFB4A/DEFB4B) and HBD-3 (DEFB103A/DEFB103B) upon infection with Mycobacterium tuberculosis and increases intracellular M. tuberculosis growth.
Entrez Gene
Summary Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:7414860-7416863
Strand Reverse strand
Band p23.1
Transcripts
ENST00000318157 ENSP00000424598
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006935 chemotaxis
GO:0006952 defense response
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005796 Golgi lumen
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_115897
Beta defensins pathway
REACT_115846
Defensins pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O15263
TrEMBL
UniProt Splice Variant
Entrez Gene 1673
UniGene Hs.740237
RefSeq NM_001205266
HUGO HGNC:30193
OMIM 602215
CCDS CCDS55193
HPRD
IMGT
EMBL AF040153 AF071216 AJ000152 BC069285 BC093983 BC093985 Z71389
GenPept AAC33549 AAC69554 AAH69285 AAH93983 AAH93985 CAA95992 CAB65126
RNA Seq Atlas 100289462 1673

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca