Bos taurus Gene: VEGFC | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-628466.3 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | VEGFC | ||||||||||||||||||||||||||
Gene Name | vascular endothelial growth factor C precursor | ||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000014737 | ||||||||||||||||||||||||||
Encoded Proteins |
vascular endothelial growth factor C
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
Summary |
[Homo sapiens] FLT4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; ligation of FLT4 by VEGFC reduces TLR4-triggered production of proinflammatory cytokines in macrophages.
[Mus musculus] Flt4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; ligation of Flt4 by Vegfc reduces TLR4-triggered production of proinflammatory cytokines in macrophages.
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Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150630:
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 27:6999636-7084866 | ||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
VEGF binds to VEGFR leading to receptor dimerization pathway
VEGF ligand-receptor interactions pathway
Signaling by VEGF pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Hemostasis pathway
Platelet degranulation pathway
Hemostasis pathway
VEGF ligand-receptor interactions pathway
Signaling by VEGF pathway
Platelet activation, signaling and aggregation pathway
VEGF binds to VEGFR leading to receptor dimerization pathway
Response to elevated platelet cytosolic Ca2+ pathway
Signal Transduction pathway
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KEGG |
Cytokine-cytokine receptor interaction pathway
Focal adhesion pathway
Pathways in cancer pathway
Cytokine-cytokine receptor interaction pathway
Focal adhesion pathway
Pathways in cancer pathway
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INOH |
VEGF signaling pathway pathway
GPCR signaling pathway
VEGF signaling pathway pathway
GPCR signaling pathway
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PID NCI |
VEGF and VEGFR signaling network
Alpha9 beta1 integrin signaling events
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | Q8WNS5 Q9XS50 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 282122 | ||||||||||||||||||||||||||
UniGene | Bt.3913 | ||||||||||||||||||||||||||
RefSeq | NM_174488 | ||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AB004275 AF009178 DAAA02060017 | ||||||||||||||||||||||||||
GenPept | AAL59422 BAA77687 | ||||||||||||||||||||||||||
RNA Seq Atlas | 282122 | ||||||||||||||||||||||||||