Version 5.4
Bos taurus Gene: DCTD
Summary
InnateDB Gene IDBG-628491.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCTD
Gene Name deoxycytidylate deaminase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020282
Encoded Proteins
IDBP-679856
deoxycytidylate deaminase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129187:
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 27:12916141-12938962
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027028 ENSBTAP00000027028
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004132 dCMP deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
Biological Process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000129187
View Gene Order
ENSMUSG00000031562
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_21376
Pyrimidine biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
REACT_238763
Pyrimidine biosynthesis pathway
REACT_236186
Pyrimidine metabolism pathway
REACT_188937
Metabolism pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
mmu00240
Pyrimidine metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL A6QQC3
UniProt Splice Variant
Entrez Gene 784292
UniGene Bt.64698
RefSeq NM_001101292
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149761 DAAA02060140 DAAA02060141
GenPept AAI49762
RNA Seq Atlas 784292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca