InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ALDH1A3

Summary

InnateDB Gene

IDBG-628582.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH1A3

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009125

Encoded Proteins

IDBP-679993

aldehyde dehydrogenase 1 family, member A3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184254:
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form. [provided by RefSeq, Jul 2008]
This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:5795677-5833339

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000012030

ENSBTAP00000012030

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity
GO:0070324	thyroid hormone binding
GO:0070403	NAD+ binding

Biological Process

GO:0002072	optic cup morphogenesis involved in camera-type eye development
GO:0002138	retinoic acid biosynthetic process
GO:0007626	locomotory behavior
GO:0008152	metabolic process
GO:0021768	nucleus accumbens development
GO:0031076	embryonic camera-type eye development
GO:0042472	inner ear morphogenesis
GO:0042573	retinoic acid metabolic process
GO:0042574	retinal metabolic process
GO:0043065	positive regulation of apoptotic process
GO:0048048	embryonic eye morphogenesis
GO:0050885	neuromuscular process controlling balance
GO:0055114	oxidation-reduction process
GO:0060013	righting reflex
GO:0060166	olfactory pit development
GO:0060324	face development