Version 5.4
Bos taurus Gene: CENPH
Summary
InnateDB Gene IDBG-628680.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CENPH
Gene Name Centromere protein H
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014246
Encoded Proteins
IDBP-680051
Centromere protein H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153044:
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:10407095-10425913
Strand Reverse strand
Band
Transcripts
ENSBTAT00000036817 ENSBTAP00000036669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043515 kinetochore binding
Biological Process
GO:0051382 kinetochore assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000153044
View Gene Order
ENSMUSG00000045273
View Gene Order
Pathways
NETPATH
REACTOME
REACT_216366
M Phase pathway
REACT_224944
Nucleosome assembly pathway
REACT_212887
Separation of Sister Chromatids pathway
REACT_217981
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_215084
Mitotic Metaphase and Anaphase pathway
REACT_211185
Mitotic Anaphase pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_214934
Cell Cycle pathway
REACT_227796
Chromosome Maintenance pathway
REACT_209545
Resolution of Sister Chromatid Cohesion pathway
REACT_203101
Mitotic Prometaphase pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_233453
Chromosome Maintenance pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_198595
Nucleosome assembly pathway
REACT_198597
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_202512
Mitotic Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3T0L1
TrEMBL
UniProt Splice Variant
Entrez Gene 505284
UniGene Bt.41747
RefSeq NM_001034236
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102350
GenPept AAI02351
RNA Seq Atlas 505284

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca