InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: COL11A2

Summary

InnateDB Gene

IDBG-628894.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL11A2

Gene Name

collagen alpha-2(XI) chain precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000601

Encoded Proteins

IDBP-680313

collagen alpha-2(XI) chain precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204248:
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:7290455-7318840

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000793

ENSBTAP00000000793

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent

Biological Process

GO:0001894	tissue homeostasis
GO:0002062	chondrocyte differentiation
GO:0007605	sensory perception of sound
GO:0030199	collagen fibril organization
GO:0048705	skeletal system morphogenesis