InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ERCC8

Summary

InnateDB Gene

IDBG-628902.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERCC8

Gene Name

DNA excision repair protein ERCC-8

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021606

Encoded Proteins

IDBP-680280

DNA excision repair protein ERCC-8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049167:
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. [provided by RefSeq, Jul 2008]
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:18372123-18423094

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028792

ENSBTAP00000028792

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0009411	response to UV
GO:0010165	response to X-ray
GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045739	positive regulation of DNA repair
GO:0051865	protein autoubiquitination

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0005634	nucleus
GO:0016363	nuclear matrix
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex
GO:0043234	protein complex