Version 5.4
Bos taurus Gene: RING1
Summary
InnateDB Gene IDBG-628967.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RING1
Gene Name E3 ubiquitin-protein ligase RING1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018884
Encoded Proteins
IDBP-680354
E3 ubiquitin-protein ligase RING1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204227:
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:7338399-7341500
Strand Forward strand
Band
Transcripts
ENSBTAT00000054269 ENSBTAP00000051371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0009952 anterior/posterior pattern specification
GO:0016574 histone ubiquitination
GO:0035518 histone H2A monoubiquitination
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048593 camera-type eye morphogenesis
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000204227
View Gene Order
ENSMUSG00000024325
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_188957
Cellular responses to stress pathway
REACT_188820
Cellular Senescence pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MUV0 Q32S20
UniProt Splice Variant
Entrez Gene 100125778
UniGene Bt.58933
RefSeq NM_001105051
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY957499 DAAA02054894 DAAA02054895
GenPept AAY34709
RNA Seq Atlas 100125778

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca