Version 5.4
| Bos taurus Gene: TAPBP | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-629016.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TAPBP | ||||||||
| Gene Name | tapasin precursor | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000016828 | ||||||||
| Encoded Proteins |
tapasin
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000231925:
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 23:7415849-7425523 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Mus musculus
Homo sapiens
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
ER-Phagosome pathway pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
ER-Phagosome pathway pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
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| KEGG |
Antigen processing and presentation pathway
Antigen processing and presentation pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | Q2NL04 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 504335 | ||||||||
| UniGene | Bt.101886 Bt.64843 | ||||||||
| RefSeq | NM_001045885 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC111269 BT029890 DAAA02054899 | ||||||||
| GenPept | AAI11270 ABM06140 | ||||||||
| RNA Seq Atlas | 504335 | ||||||||