Version 5.4
Bos taurus Gene: ERLIN2
Summary
InnateDB Gene IDBG-629031.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERLIN2
Gene Name Erlin-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017831
Encoded Proteins
IDBP-680429
Erlin-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147475:
This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 27:32721072-32738208
Strand Forward strand
Band
Transcripts
ENSBTAT00000039803 ENSBTAP00000039591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000147475
View Gene Order
ENSMUSG00000031483
View Gene Order
Cross-References
SwissProt Q1RMU4
TrEMBL
UniProt Splice Variant
Entrez Gene 616278
UniGene Bt.1734
RefSeq NM_001046576 XM_005226124 XM_005226125 XM_005226126
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114707
GenPept AAI14708
RNA Seq Atlas 616278

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca