InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HTR2A

Summary

InnateDB Gene

IDBG-629040.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR2A

Gene Name

5-hydroxytryptamine receptor 2A

Synonyms

5HT2A; 5HTR2A

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013498

Encoded Proteins

IDBP-680430

5-hydroxytryptamine receptor 2A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102468:
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:16823524-16889281

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017943

ENSBTAP00000017943

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0008144	drug binding
GO:0051378	serotonin binding
GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007210	serotonin receptor signaling pathway
GO:0007610	behavior
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0033674	positive regulation of kinase activity
GO:0042493	response to drug
GO:0044380	protein localization to cytoskeleton
GO:0045821	positive regulation of glycolytic process
GO:0046883	regulation of hormone secretion
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050795	regulation of behavior
GO:0051209	release of sequestered calcium ion into cytosol
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0042995	cell projection
GO:0043198	dendritic shaft