Bos taurus Gene: BCAR1 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-629067.3 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | BCAR1 | ||||||||||||||||||||||||||
Gene Name | Uncharacterized protein | ||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000012002 | ||||||||||||||||||||||||||
Encoded Proteins |
breast cancer anti-estrogen resistance 1
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
Summary |
[Homo sapiens] BCAR1 acts as a primary force sensor, transducing force into mechanical extension and thereby priming phosphorylation and activation of downstream signalling whereby tyrosine phosphorylation of BCRA1 in a cytoskeletal complex is involved in force-dependent activation of the small GTPase RAP1A.
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Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000050820:
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 18:2613213-2625218 | ||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH |
EGFR1 pathway
TGF_beta_Receptor pathway
BCR pathway
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REACTOME |
p130Cas linkage to MAPK signaling for integrins pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signaling by VEGF pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
VEGFA-VEGFR2 Pathway pathway
Hemostasis pathway
Hemostasis pathway
Signaling by VEGF pathway
Platelet activation, signaling and aggregation pathway
Downstream signal transduction pathway
VEGFA-VEGFR2 Pathway pathway
Signaling by PDGF pathway
p130Cas linkage to MAPK signaling for integrins pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Chemokine signaling pathway pathway
Bacterial invasion of epithelial cells pathway
Regulation of actin cytoskeleton pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Chemokine signaling pathway pathway
Bacterial invasion of epithelial cells pathway
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INOH |
Integrin signaling pathway pathway
Integrin signaling pathway pathway
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PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
LPA receptor mediated events
CXCR4-mediated signaling events
Netrin-mediated signaling events
Integrins in angiogenesis
Signaling events mediated by PTP1B
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Alpha9 beta1 integrin signaling events
Signaling events mediated by focal adhesion kinase
IGF1 pathway
RAC1 signaling pathway
Endothelins
Signaling events mediated by PRL
CDC42 signaling events
Plasma membrane estrogen receptor signaling
Signaling events regulated by Ret tyrosine kinase
Alpha4 beta1 integrin signaling events
EPHA2 forward signaling
PDGFR-beta signaling pathway
Osteopontin-mediated events
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||