Version 5.4
Bos taurus Gene: PPAP2A
Summary
InnateDB Gene IDBG-629135.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPAP2A
Gene Name lipid phosphate phosphohydrolase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010526
Encoded Proteins
IDBP-680527
lipid phosphate phosphohydrolase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067113:
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:23658802-23793336
Strand Forward strand
Band
Transcripts
ENSBTAT00000047359 ENSBTAP00000044571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008195 phosphatidate phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0006629 lipid metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000067113
View Gene Order
ENSMUSG00000021759
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_198151
Sphingolipid de novo biosynthesis pathway
REACT_188937
Metabolism pathway
REACT_245163
Sphingolipid metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa00561
Glycerolipid metabolism pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04975
Fat digestion and absorption pathway
mmu00564
Glycerophospholipid metabolism pathway
mmu00600
Sphingolipid metabolism pathway
mmu00565
Ether lipid metabolism pathway
mmu00561
Glycerolipid metabolism pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04975
Fat digestion and absorption pathway
INOH
PID NCI
p73pathway
p73 transcription factor network
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL Q32KV9
UniProt Splice Variant
Entrez Gene 617172
UniGene Bt.103208
RefSeq NM_001080329
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109901 DAAA02050342 DAAA02050343 DAAA02050344
GenPept AAI09902
RNA Seq Atlas 617172

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca