Version 5.4
Homo sapiens Gene: PTX3
Summary
InnateDB Gene IDBG-62945.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTX3
Gene Name pentraxin 3, long
Synonyms TNFAIP5; TSG-14
Species Homo sapiens
Ensembl Gene ENSG00000163661
Encoded Proteins
IDBP-62947
pentraxin 3, long
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19050261
PTX3 is a multifunctional soluble molecule involved in inflammation and innate immunity. It is a unique factor H (FH) ligand in that it can bind both of the two hot-spots of FH and can participate in the localization of functionally active FH.
PMID 20208538
PTX3, an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and glycosylation-dependent regulation of inflammation.
PMID 20363749
PTX3, an inflammation-associated long pentraxin, plays key roles in innate immunity, female fertility and vascular biology. PTX3 octamer contains two fibroblast growth factor 2 (FGF2) binding sites and this quaternary organization is required for the anti-angiogenic function of PTX3.
PMID 20683616
PTX3 is produced by innate immunity cells (e.g. PMN, macrophages, dendritic cells) and it interacts with several ligands to play an essential role in innate immunity, tuning inflammation and matrix deposition. PTX3 provides a paradigm for the mode of action of humoral innate immunity.
PMID 21106539
PTX3, serum amyloid P component (SAP) and C-reactive protein (CRP) belong to the pentraxin family of pattern recognition molecules involved in tissue homeostasis and innate immunity. PTX3 heterocomplexes with mannose-binding lectin (MBL) to trigger cross-activation of the complement system.
PMID 21465531
PTX3 production is up-regulated in response to serum amyloid A, and contributes to the inflammatory pathogenesis of atherosclerosis.
PMID 21490156
FCN3 and PTX3 are soluble oligomeric pattern-recognition molecules that interact with each other and act synergistically to activate the lectin complement pathway.
PMID 22278372
PTX3 forms a complex with components of neutrophil extracellular traps in septic patients.
PMID 23475792
Sputum PTX3 level are lower in cystic fibrosis patients due to proteolytic cleavage by Aspergillus fumigatus.
PMID 25679762
PTX3 acts as an extrinsic oncosuppressor gene by regulating Complement-dependent, macrophage-sustained, tumor-promoting inflammation.
PMID 25964372
PTX3 plays a non-redundant protective role in orchestrating tissue repair and remodeling by interacting with fibrin and plasminogen.
InnateDB Annotation from Orthologs
Summary
PMID 21465531
[Mus musculus] Ptx3 production is up-regulated in response to serum amyloid A, and contributes to the inflammatory pathogenesis of atherosclerosis. (Demonstrated in human)
PMID 22278372
[Mus musculus] Ptx3 forms a complex with components of neutrophil extracellular traps in septic patients. (Demonstrated in human)
PMID 25679762
[Mus musculus] Ptx3 acts as an extrinsic oncosuppressor gene by regulating Complement-dependent, macrophage-sustained, tumor-promoting inflammation.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:157436789-157443628
Strand Forward strand
Band q25.32
Transcripts
ENST00000295927 ENSP00000295927
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001849 complement component C1q binding
GO:0001872 (1->3)-beta-D-glucan binding
GO:0046790 virion binding
Biological Process
GO:0001878 response to yeast
GO:0006954 inflammatory response
GO:0008228 opsonization
GO:0045087 innate immune response (InnateDB)
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046597 negative regulation of viral entry into host cell
GO:0050766 positive regulation of phagocytosis
GO:1903016 negative regulation of exo-alpha-sialidase activity
GO:1903019 negative regulation of glycoprotein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027832
View Gene Order
ENSBTAG00000009012
Not yet available
Cross-References
SwissProt P26022
TrEMBL
UniProt Splice Variant
Entrez Gene 5806
UniGene Hs.591286 Hs.667287
RefSeq NM_002852
HUGO HGNC:9692
OMIM 602492
CCDS CCDS3180
HPRD
IMGT
EMBL AC020630 AK312705 BC039733 CH471052 DQ207368 M31166 X63053 X63613
GenPept AAA61234 AAH39733 ABA64467 BAG35583 CAA44778 CAA45158 EAW78708
RNA Seq Atlas 5806

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca