InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BLM

Summary

InnateDB Gene

IDBG-629490.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BLM

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020301

Encoded Proteins

IDBP-680965

Bloom syndrome, RecQ helicase-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197299:
The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq, Jul 2008]
The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3\'-5\' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:22264540-22331807

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000027057

ENSBTAP00000027057

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000405	bubble DNA binding
GO:0002039	p53 binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0003824	catalytic activity
GO:0004003	ATP-dependent DNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016887	ATPase activity
GO:0036310	annealing helicase activity
GO:0043140	ATP-dependent 3'-5' DNA helicase activity
GO:0051880	G-quadruplex DNA binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000723	telomere maintenance
GO:0000729	DNA double-strand break processing
GO:0000733	DNA strand renaturation
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0010165	response to X-ray
GO:0031297	replication fork processing
GO:0032508	DNA duplex unwinding
GO:0044237	cellular metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045910	negative regulation of DNA recombination
GO:0045950	negative regulation of mitotic recombination
GO:0046632	alpha-beta T cell differentiation
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0051098	regulation of binding
GO:0051259	protein oligomerization
GO:0051276	chromosome organization
GO:0051782	negative regulation of cell division
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0071479	cellular response to ionizing radiation
GO:0072711	cellular response to hydroxyurea
GO:0072757	cellular response to camptothecin

Cellular Component

GO:0000228	nuclear chromosome
GO:0000781	chromosome, telomeric region
GO:0000800	lateral element
GO:0001673	male germ cell nucleus
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0016605	PML body
GO:0045120	pronucleus