Version 5.4
| Bos taurus Gene: CD247 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-629556.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | CD247 | ||||||||||
| Gene Name | T-cell surface glycoprotein CD3 zeta chain precursor | ||||||||||
| Synonyms | CD3Z | ||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000012700 | ||||||||||
| Encoded Proteins |
T-cell surface glycoprotein CD3 zeta chain
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198821:
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 3:1230988-1314962 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH |
TCR pathway
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| REACTOME |
PD-1 signaling pathway
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Role of phospholipids in phagocytosis pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Downstream TCR signaling pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Immune System pathway
FCGR activation pathway
Translocation of ZAP-70 to Immunological synapse pathway
Costimulation by the CD28 family pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
TCR signaling pathway
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| KEGG |
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Chagas disease (American trypanosomiasis) pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
CD4 T cell receptor signaling pathway
CD4 T cell receptor signaling pathway
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| PID NCI |
TCR signaling in naïve CD8+ T cells
CXCR4-mediated signaling events
TCR signaling in naïve CD4+ T cells
Downstream signaling in naïve CD8+ T cells
IL12-mediated signaling events
IL12 signaling mediated by STAT4
HIV-1 Nef: Negative effector of Fas and TNF-alpha
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| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | |||||||||||
| UniGene | Bt.4763 | ||||||||||
| RefSeq | NM_174012 XM_005203420 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | |||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | |||||||||||