InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.19792

Summary

InnateDB Gene

IDBG-629572.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.19792

Gene Name

indoleamine 2,3-dioxygenase 1

Synonyms

INDO

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020602

Encoded Proteins

IDBP-680984

indoleamine 2,3-dioxygenase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22355111

[Homo sapiens] IDO1 limits innate and adaptive immunity to apoptotic self-antigens. IDO1-mediated inhibition of inflammation plays a key role in suppressing systemic autoimmune diseases. (Demonstrated in mice)

PMID 23986532

[Homo sapiens] DNA nanoparticle is sensed selectively by myeloid dendritic cells (DCs) via the STING (for stimulator of interferon genes) /type I IFN pathway to induce Ido1 in DCs, which activate regulatory T cells.

PMID 22355111

[Mus musculus] Ido1 limits innate and adaptive immunity to apoptotic self-antigens. Ido1-mediated inhibition of inflammation plays a key role in suppressing systemic autoimmune diseases.

PMID 26857571

[Mus musculus] Uropathogenic Escherichia coli suppresses neutrophil migration early in bacterial cystitis by eliciting an Ido1-mediated increase in local production of kynurenines, which act through the Ahr to impair neutrophil chemotaxis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131203:
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 27:34686577-34699480

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027449

ENSBTAP00000027449

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004833	tryptophan 2,3-dioxygenase activity
GO:0005515	protein binding
GO:0020037	heme binding

Biological Process

GO:0002534	cytokine production involved in inflammatory response
GO:0002666	positive regulation of T cell tolerance induction
GO:0002678	positive regulation of chronic inflammatory response
GO:0002830	positive regulation of type 2 immune response
GO:0006954	inflammatory response
GO:0019441	tryptophan catabolic process to kynurenine
GO:0032496	response to lipopolysaccharide
GO:0032693	negative regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0033555	multicellular organismal response to stress
GO:0034276	kynurenic acid biosynthetic process
GO:0036269	swimming behavior
GO:0042130	negative regulation of T cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0046007	negative regulation of activated T cell proliferation
GO:0055114	oxidation-reduction process
GO:0070233	negative regulation of T cell apoptotic process