Version 5.4
| Bos taurus Gene: UPF3B | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-629709.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | UPF3B | ||||||||||
| Gene Name | regulator of nonsense transcripts 3B | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000035615 | ||||||||||
| Encoded Proteins |
UPF3 regulator of nonsense transcripts homolog B
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125351:
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome X:4015335-4032280 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
mRNA 3'-end processing pathway
mRNA Splicing - Major Pathway pathway
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Cleavage of Growing Transcript in the Termination Region pathway
Nonsense-Mediated Decay (NMD) pathway
RNA Polymerase II Transcription Termination pathway
RNA Polymerase II Transcription pathway
Transport of Mature Transcript to Cytoplasm pathway
mRNA Splicing pathway
Gene Expression pathway
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| KEGG |
RNA transport pathway
mRNA surveillance pathway pathway
RNA transport pathway
mRNA surveillance pathway pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | Q2T9M5 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 616181 | ||||||||||
| UniGene | Bt.89290 | ||||||||||
| RefSeq | NM_001076411 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | BC111353 DAAA02067145 DAAA02067146 | ||||||||||
| GenPept | AAI11354 | ||||||||||
| RNA Seq Atlas | 100852254 616181 | ||||||||||