Version 5.4
Bos taurus Gene: CUL4B
Summary
InnateDB Gene IDBG-629803.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CUL4B
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018569
Encoded Proteins
IDBP-681286
cullin 4B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158290:
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:4752579-4783555
Strand Forward strand
Band
Transcripts
ENSBTAT00000024713 ENSBTAP00000024713
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 265 interaction(s) predicted by orthology.
Predicted by orthology
Total 265 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0035518 histone H2A monoubiquitination
GO:0045732 positive regulation of protein catabolic process
GO:0070914 UV-damage excision repair
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000158290
View Gene Order
ENSMUSG00000031095
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa03420
Nucleotide excision repair pathway
mmu04120
Ubiquitin mediated proteolysis pathway
mmu03420
Nucleotide excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BFD5
UniProt Splice Variant
Entrez Gene 539668
UniGene Bt.65667
RefSeq XM_002699510 XM_005227472 XM_005227473 XM_005227474 XM_588651
HUGO HGNC:2555
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02067221 DAAA02067222
GenPept
RNA Seq Atlas 100850189 539668

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca