InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PPARD

Summary

InnateDB Gene

IDBG-629858.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARD

Gene Name

peroxisome proliferator-activated receptor delta

Synonyms

PPAR-beta

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017542

Encoded Proteins

IDBP-681290

peroxisome proliferator-activated receptor delta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112033:
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:9340955-9353750

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023319

ENSBTAP00000023319

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0070539	linoleic acid binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001890	placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008366	axon ensheathment
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015908	fatty acid transport
GO:0030154	cell differentiation
GO:0031589	cell-substrate adhesion
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0042640	anagen
GO:0043401	steroid hormone mediated signaling pathway
GO:0043616	keratinocyte proliferation
GO:0045598	regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051546	keratinocyte migration
GO:0060612	adipose tissue development
GO:0071456	cellular response to hypoxia
GO:0097190	apoptotic signaling pathway