Version 5.4
| Bos taurus Gene: ATF6 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-629937.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | ATF6 | ||||||||
| Gene Name | Uncharacterized protein | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000005227 | ||||||||
| Encoded Proteins |
activating transcription factor 6
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118217:
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 3:7613876-7843250 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
ATF4 activates genes pathway
PERK regulates gene expression pathway
ATF6-alpha activates chaperone genes pathway
ATF6-alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Metabolism of proteins pathway
ATF6-alpha activates chaperone genes pathway
Unfolded Protein Response (UPR) pathway
Metabolism of proteins pathway
PERK regulates gene expression pathway
ATF6-alpha activates chaperones pathway
ATF4 activates genes pathway
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| KEGG |
Alzheimer's disease pathway
Protein processing in endoplasmic reticulum pathway
Alzheimer's disease pathway
Protein processing in endoplasmic reticulum pathway
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| INOH | |||||||||
| PID NCI |
Signaling mediated by p38-alpha and p38-beta
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | F1MDD8 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 530610 | ||||||||
| UniGene | Bt.75127 | ||||||||
| RefSeq | XM_003581916 XM_003585816 | ||||||||
| HUGO | HGNC:791 | ||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02006938 DAAA02006939 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 530610 | ||||||||