InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LIFR

Summary

InnateDB Gene

IDBG-630017.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIFR

Gene Name

leukemia inhibitory factor receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010423

Encoded Proteins

IDBP-681463

leukemia inhibitory factor receptor alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113594:
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:35917479-35966671

Strand

Forward strand

Band

Transcripts

ENSBTAT00000013754

ENSBTAP00000013754

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004897	ciliary neurotrophic factor receptor activity
GO:0004923	leukemia inhibitory factor receptor activity
GO:0004924	oncostatin-M receptor activity
GO:0005127	ciliary neurotrophic factor receptor binding
GO:0005515	protein binding
GO:0019838	growth factor binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0034097	response to cytokine
GO:0038165	oncostatin-M-mediated signaling pathway
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway