Version 5.4
Bos taurus Gene: RDX
Summary
InnateDB Gene IDBG-630088.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RDX
Gene Name radixin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004672
Encoded Proteins
IDBP-681531
radixin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137710:
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:20589674-20650077
Strand Reverse strand
Band
Transcripts
ENSBTAT00000006129 ENSBTAP00000006129
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0010628 positive regulation of gene expression
GO:0030033 microvillus assembly
GO:0045176 apical protein localization
GO:0061028 establishment of endothelial barrier
Cellular Component
GO:0001726 ruffle
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005925 focal adhesion
GO:0019898 extrinsic component of membrane
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0032420 stereocilium
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137710
View Gene Order
ENSMUSG00000032050
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
mmu04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A6QQJ5 F1MJJ8
UniProt Splice Variant
Entrez Gene 517111
UniGene Bt.35977
RefSeq NM_001075749
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149864 DAAA02040250
GenPept AAI49865
RNA Seq Atlas 517111

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca