Version 5.4
| Bos taurus Gene: SH2D1A | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-630222.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | SH2D1A | ||||||||||
| Gene Name | SH2 domain-containing protein 1A | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000026067 | ||||||||||
| Encoded Proteins |
SH2 domain-containing protein 1A
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] The SLAM and SAP gene families control innate and adaptive immune responses
[Homo sapiens] SLAM receptors and SAP influence lymphocyte interactions, development and function
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183918:
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome X:8248270-8268594 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME | |||||||||||
| KEGG |
Natural killer cell mediated cytotoxicity pathway
Natural killer cell mediated cytotoxicity pathway
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| INOH | |||||||||||
| PID NCI |
Direct p53 effectors
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| Cross-References | |||||||||||
| SwissProt | Q3ZBB1 | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 613356 | ||||||||||
| UniGene | Bt.49406 | ||||||||||
| RefSeq | NM_001034733 XM_005227470 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | BC103462 | ||||||||||
| GenPept | AAI03463 | ||||||||||
| RNA Seq Atlas | 613356 | ||||||||||