Version 5.4
Bos taurus Gene: JAM2
Summary
InnateDB Gene IDBG-630318.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JAM2
Gene Name junctional adhesion molecule B precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000603
Encoded Proteins
IDBP-681768
junctional adhesion molecule B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154721:
This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:10083035-10165613
Strand Reverse strand
Band
Transcripts
ENSBTAT00000000795 ENSBTAP00000000795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007162 negative regulation of cell adhesion
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000154721
View Gene Order
ENSMUSG00000053062
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_206066
Extracellular matrix organization pathway
REACT_216309
Integrin cell surface interactions pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
mmu04530
Tight junction pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04670
Leukocyte transendothelial migration pathway
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL A4IFI9
UniProt Splice Variant
Entrez Gene 538846
UniGene Bt.18203
RefSeq NM_001083736
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134600 DAAA02000242
GenPept AAI34601
RNA Seq Atlas 538846

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca