Version 5.4
Bos taurus Gene: IL2
Summary
InnateDB Gene IDBG-630322.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL2
Gene Name Interleukin-2
Synonyms IL-2; TCGF
Species Bos taurus
Ensembl Gene ENSBTAG00000020883
Encoded Proteins
IDBP-681773
Interleukin-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35618100-35622852
Strand Forward strand
Band
Transcripts
ENSBTAT00000027819 ENSBTAP00000027819
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005134 interleukin-2 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0002376 immune system process
GO:0002903 negative regulation of B cell apoptotic process
GO:0006955 immune response
GO:0030890 positive regulation of B cell proliferation
GO:0032729 positive regulation of interferon-gamma production
GO:0032740 positive regulation of interleukin-17 production
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046013 regulation of T cell homeostatic proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050728 negative regulation of inflammatory response
GO:0051024 positive regulation of immunoglobulin secretion
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_205369
Signaling by GPCR pathway
REACT_226349
Interleukin-2 signaling pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_223657
Interleukin receptor SHC signaling pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_214353
Signal Transduction pathway
REACT_219098
GPVI-mediated activation cascade pathway
REACT_214436
GPCR downstream signaling pathway
REACT_203136
G-protein beta:gamma signalling pathway
REACT_211267
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_206833
Signaling by Interleukins pathway
REACT_202218
G beta:gamma signalling through PI3Kgamma pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P05016
TrEMBL B2BB68 G8JKZ2
UniProt Splice Variant
Entrez Gene 280822
UniGene Bt.341
RefSeq NM_180997 XM_005217599
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF348423 AF535144 DAAA02044765 EF056472 EF118499 EF118500 EF118501 EF118502 EF118503 EF118504 EF118505 EF118506 EF118507 EF118508 EF118509 EF118510 EF118511 EF118512 EF118513 EF118514 EF118515 EF118516 EF118517 EF118518 EF118519 EF118520 EF118521 EF118522 EF118523 EF118524 EF118525 EF118526 EF118527 EF118528 EF118529 EF118530 EF118531 EF118532 EF118533 EF118534 EF118535 EF118536 EF118537 EF118538 EF118539 EF118540 EF118541 EF118542 EF118543 EF118544 EF118545 EF118546 EF118547 EF118548 EF118549 EF118550 EF118551 EF118552 EF118553 EF118554 EF118555 EF118556 EF118557 EF118558 EF118559 EF118560 EU276068 M12791 M13204 X17201 X52687
GenPept AAA21143 AAA30586 AAN76508 AAQ10670 ABK41607 ABO69855 ABO69856 ABO69857 ABO69858 ABO69859 ABO69860 ABO69861 ABO69862 ABO69863 ABO69864 ABO69865 ABO69866 ABO69867 ABO69868 ABO69869 ABO69870 ABO69871 ABO69872 ABO69873 ABO69874 ABO69875 ABO69876 ABO69877 ABO69878 ABO69879 ABO69880 ABO69881 ABO69882 ABO69883 ABO69884 ABO69885 ABO69886 ABO69887 ABO69888 ABO69889 ABO69890 ABO69891 ABO69892 ABO69893 ABO69894 ABO69895 ABO69896 ABO69897 ABO69898 ABO69899 ABO69900 ABO69901 ABO69902 ABO69903 ABO69904 ABO69905 ABO69906 ABO69907 ABO69908 ABO69909 ABO69910 ABO69911 ABO69912 ABO69913 ABO69914 ABO69915 ABO69916 ABX72066 CAA35062 CAA36912
RNA Seq Atlas 280822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca