InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DRD2

Summary

InnateDB Gene

IDBG-630610.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRD2

Gene Name

D(2) dopamine receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010860

Encoded Proteins

IDBP-682081

D(2) dopamine receptor

IDBP-682082

D(2) dopamine receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23242137

[Mus musculus] DRD2 activation in astrocytes suppresses neuroinflammation in the central nervous system through CRYAB.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149295:
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:24303204-24316174

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014422	ENSBTAP00000014422
ENSBTAT00000063318	ENSBTAP00000053928

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0035240	dopamine binding
GO:0042802	identical protein binding

Biological Process

GO:0001659	temperature homeostasis
GO:0001964	startle response
GO:0001975	response to amphetamine
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure
GO:0002027	regulation of heart rate
GO:0002028	regulation of sodium ion transport
GO:0002052	positive regulation of neuroblast proliferation
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007270	neuron-neuron synaptic transmission
GO:0007409	axonogenesis
GO:0007608	sensory perception of smell
GO:0007625	grooming behavior
GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0007631	feeding behavior
GO:0008104	protein localization
GO:0008285	negative regulation of cell proliferation
GO:0008306	associative learning
GO:0008542	visual learning
GO:0009416	response to light stimulus
GO:0014059	regulation of dopamine secretion
GO:0021853	cerebral cortex GABAergic interneuron migration
GO:0021984	adenohypophysis development
GO:0030336	negative regulation of cell migration
GO:0030432	peristalsis
GO:0030534	adult behavior
GO:0030814	regulation of cAMP metabolic process
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0032467	positive regulation of cytokinesis
GO:0032922	circadian regulation of gene expression
GO:0034776	response to histamine
GO:0035556	intracellular signal transduction
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0040018	positive regulation of multicellular organism growth
GO:0042220	response to cocaine
GO:0042417	dopamine metabolic process
GO:0042493	response to drug
GO:0043266	regulation of potassium ion transport
GO:0043278	response to morphine
GO:0043473	pigmentation
GO:0045776	negative regulation of blood pressure
GO:0048148	behavioral response to cocaine
GO:0048149	behavioral response to ethanol
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048755	branching morphogenesis of a nerve
GO:0050482	arachidonic acid secretion
GO:0050709	negative regulation of protein secretion
GO:0050804	regulation of synaptic transmission
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051584	regulation of dopamine uptake involved in synaptic transmission
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission
GO:0051898	negative regulation of protein kinase B signaling
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060124	positive regulation of growth hormone secretion
GO:0060134	prepulse inhibition
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
GO:0060160	negative regulation of dopamine receptor signaling pathway
GO:1901386	negative regulation of voltage-gated calcium channel activity