Version 5.4
Bos taurus Gene: ROBO1
Summary
InnateDB Gene IDBG-630648.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ROBO1
Gene Name roundabout homolog 1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009851
Encoded Proteins
IDBP-682130
roundabout, axon guidance receptor, homolog 1 (Drosophila)
IDBP-682133
roundabout, axon guidance receptor, homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169855:
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:25620170-26210494
Strand Reverse strand
Band
Transcripts
ENSBTAT00000048615 ENSBTAP00000045620
ENSBTAT00000061264 ENSBTAP00000053683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030275 LRR domain binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007156 homophilic cell adhesion
GO:0007411 axon guidance
GO:0008285 negative regulation of cell proliferation
GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0035385 Roundabout signaling pathway
GO:0050772 positive regulation of axonogenesis
GO:0050925 negative regulation of negative chemotaxis
GO:0060763 mammary duct terminal end bud growth
GO:0070100 negative regulation of chemokine-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030673 axolemma
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000169855
View Gene Order
ENSMUSG00000022883
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19230
Role of Abl in Robo-Slit signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_19226
Activation of Rac pathway
REACT_19342
Inactivation of Cdc42 and Rac pathway
REACT_19376
Regulation of Commissural axon pathfinding by Slit and Robo pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
mmu04360
Axon guidance pathway
INOH
PID NCI
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL F1N279 F1N739
UniProt Splice Variant
Entrez Gene 536815
UniGene Bt.110068
RefSeq NM_001192888 XM_005201165 XM_005201166 XM_005201168 XM_005201169
HUGO HGNC:10249
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02000591 DAAA02000592 DAAA02000593 DAAA02000594 DAAA02000595 DAAA02000596 DAAA02000597 DAAA02000598 DAAA02000599 DAAA02000600 DAAA02000601 DAAA02000602 DAAA02000603 DAAA02000604 DAAA02000605
GenPept
RNA Seq Atlas 536815

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca