InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.46244

Summary

InnateDB Gene

IDBG-630731.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.46244

Gene Name

homeobox protein CDX-2

Synonyms

CDX-2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001819

Encoded Proteins

IDBP-682209

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165556:
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:32317772-32322605

Strand

Forward strand

Band

Transcripts

ENSBTAT00000047376

ENSBTAP00000044587

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0001824	blastocyst development
GO:0001829	trophectodermal cell differentiation
GO:0001890	placenta development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0008333	endosome to lysosome transport
GO:0009952	anterior/posterior pattern specification
GO:0030154	cell differentiation
GO:0035019	somatic stem cell maintenance
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0045597	positive regulation of cell differentiation
GO:0060711	labyrinthine layer development