Version 5.4
Bos taurus Gene: BT.27077
Summary
InnateDB Gene IDBG-630777.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.27077
Gene Name Duffy antigen/chemokine receptor
Synonyms DARC
Species Bos taurus
Ensembl Gene ENSBTAG00000003220
Encoded Proteins
IDBP-682259
Duffy antigen/chemokine receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213088:
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:10647427-10648940
Strand Reverse strand
Band
Transcripts
ENSBTAT00000004179 ENSBTAP00000004179
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0019956 chemokine binding
GO:0019957 C-C chemokine binding
Biological Process
GO:0006954 inflammatory response
GO:0032642 regulation of chemokine production
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000037872
View Gene Order
ENSG00000213088
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
mmu05144
Malaria pathway
hsa05144
Malaria pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N018
UniProt Splice Variant
Entrez Gene 528076
UniGene Bt.27077
RefSeq NM_001015634
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02007007
GenPept
RNA Seq Atlas 528076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca