InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPTA1

Summary

InnateDB Gene

IDBG-630820.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTA1

Gene Name

spectrin alpha chain, erythrocyte

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000888

Encoded Proteins

IDBP-682383

spectrin, alpha, erythrocytic 1 (elliptocytosis 2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163554:
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:11111861-11204434

Strand

Forward strand

Band

Transcripts

ENSBTAT00000061417

ENSBTAP00000053194

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002260	lymphocyte homeostasis
GO:0006779	porphyrin-containing compound biosynthetic process
GO:0007009	plasma membrane organization
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0030097	hemopoiesis
GO:0032092	positive regulation of protein binding
GO:0042102	positive regulation of T cell proliferation