InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RNF6

Summary

InnateDB Gene

IDBG-630844.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF6

Gene Name

E3 ubiquitin-protein ligase RNF6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005318

Encoded Proteins

IDBP-682329

RING finger protein 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127870:
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:33409894-33419168

Strand

Forward strand

Band

Transcripts

ENSBTAT00000047301

ENSBTAP00000044516

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding
GO:0050681	androgen receptor binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0030517	negative regulation of axon extension
GO:0044314	protein K27-linked ubiquitination
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070936	protein K48-linked ubiquitination
GO:0085020	protein K6-linked ubiquitination