Version 5.4
Bos taurus Gene: RFFL
Summary
InnateDB Gene IDBG-630885.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFFL
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013645
Encoded Proteins
IDBP-682391
ring finger and FYVE-like domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092871:
Gene Information
Type Protein coding
Genomic Location Chromosome 19:15378253-15400325
Strand Forward strand
Band
Transcripts
ENSBTAT00000018136 ENSBTAP00000018136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006886 intracellular protein transport
GO:0010762 regulation of fibroblast migration
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936 protein K48-linked ubiquitination
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
Cellular Component
GO:0002947 tumor necrosis factor receptor superfamily complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000092871
View Gene Order
ENSMUSG00000020696
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
tnfpathway
TNF receptor signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.64563
RefSeq XM_002695631 XM_005192865 XM_005192866 XM_005192867 XM_005192868 XM_005192869 XM_005220051 XM_005220052 XM_005220053 XM_005220054 XM_005220055 XM_867129
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca