InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NDUFA12

Summary

InnateDB Gene

IDBG-630908.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFA12

Gene Name

NADH dehydrogenase

Synonyms

DAP13

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014669

Encoded Proteins

IDBP-682396

NADH dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184752:
This gene encodes a protein which is part of mitochondrial complex 1, part of the oxidative phosphorylation system in mitochondria. Complex 1 transfers electrons to ubiquinone from NADH which establishes a proton gradient for the generation of ATP. Mutations in this gene are associated with Leigh syndrome due to mitochondrial complex 1 deficiency. Pseudogenes of this gene are located on chromosomes 5 and 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:24846225-24873123

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019529

ENSBTAP00000019529

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0009055	electron carrier activity

Biological Process

GO:0006979	response to oxidative stress
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0016020	membrane
GO:0070469	respiratory chain