InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SAP18

Summary

InnateDB Gene

IDBG-631159.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAP18

Gene Name

Histone deacetylase complex subunit SAP18

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018631

Encoded Proteins

IDBP-682662

Histone deacetylase complex subunit SAP18

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150459:
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:35860636-35868470

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024791

ENSBTAP00000024791

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 100 interaction(s) predicted by orthology.

Predicted by orthology
Total	100 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043065	positive regulation of apoptotic process
GO:0048025	negative regulation of mRNA splicing, via spliceosome