Version 5.4
Bos taurus Gene: RTKN
Summary
InnateDB Gene IDBG-631322.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTKN
Gene Name rhotekin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000490
Encoded Proteins
IDBP-682846
rhotekin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114993:
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:10171697-10185979
Strand Forward strand
Band
Transcripts
ENSBTAT00000000619 ENSBTAP00000000619
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0017048 Rho GTPase binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0007165 signal transduction
GO:0007266 Rho protein signal transduction
GO:0043086 negative regulation of catalytic activity
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000114993
View Gene Order
ENSMUSG00000034930
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MS34
UniProt Splice Variant
Entrez Gene 539691
UniGene Bt.2441
RefSeq NM_001034681 XM_005212449
HUGO HGNC:10466
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030324
GenPept
RNA Seq Atlas 539691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca