InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GJB2

Summary

InnateDB Gene

IDBG-631326.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GJB2

Gene Name

Gap junction beta-2 protein

Synonyms

CX26

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017425

Encoded Proteins

IDBP-682845

Gap junction beta-2 protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165474:
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50%% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:36335916-36340957

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023167

ENSBTAP00000023167

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005243	gap junction channel activity
GO:0005515	protein binding

Biological Process

GO:0007154	cell communication
GO:0007267	cell-cell signaling
GO:0007605	sensory perception of sound
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0005922	connexon complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction