Version 5.4
Bos taurus Gene: PION
Summary
InnateDB Gene IDBG-631380.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PION
Gene Name gamma-secretase-activating protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018430
Encoded Proteins
IDBP-682920
pigeon homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186088:
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:44061014-44149466
Strand Forward strand
Band
Transcripts
ENSBTAT00000024520 ENSBTAP00000024520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
Biological Process
GO:0030162 regulation of proteolysis
GO:1902004 positive regulation of beta-amyloid formation
Cellular Component
GO:0005802 trans-Golgi network
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000186088
View Gene Order
ENSMUSG00000039934
View Gene Order
Cross-References
SwissProt
TrEMBL F1MBQ5
UniProt Splice Variant
Entrez Gene 615147
UniGene Bt.64098
RefSeq NM_001193061
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02010498 DAAA02010499
GenPept
RNA Seq Atlas 615147

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca