Version 5.4
Homo sapiens Gene: LRTOMT
Summary
InnateDB Gene IDBG-63145.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRTOMT
Gene Name leucine rich transmembrane and 0-methyltransferase domain containing
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184154
Encoded Proteins
IDBP-586847
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-63147
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-63149
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-376205
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-380255
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-380257
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-380258
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-380259
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-380261
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-587389
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-592418
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-599471
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-593274
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-589984
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-596146
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-600087
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-603845
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-593777
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-590684
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-588341
leucine rich transmembrane and 0-methyltransferase domain containing
IDBP-809122
leucine rich transmembrane and O-methyltransferase domain containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene. [provided by RefSeq, Sep 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:72080331-72110782
Strand Forward strand
Band q13.4
Transcripts
ENST00000324866 ENSP00000440693
ENST00000289488 ENSP00000289488
ENST00000307198 ENSP00000305742
ENST00000440313 ENSP00000390485
ENST00000419228 ENSP00000392233
ENST00000435085 ENSP00000409789
ENST00000427369 ENSP00000409403
ENST00000447974 ENSP00000414271
ENST00000412777
ENST00000439209 ENSP00000395139
ENST00000423494 ENSP00000441249
ENST00000538413 ENSP00000438762
ENST00000535883 ENSP00000437561
ENST00000539271 ENSP00000442267
ENST00000539587 ENSP00000437649
ENST00000538478 ENSP00000444583
ENST00000544409 ENSP00000440969
ENST00000542846 ENSP00000440248
ENST00000541614 ENSP00000438522
ENST00000537483 ENSP00000437985
ENST00000536917 ENSP00000443421
ENST00000541899
ENST00000615940 ENSP00000482923
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008171 O-methyltransferase activity
GO:0016206 catechol O-methyltransferase activity
Biological Process
GO:0007605 sensory perception of sound
GO:0032259 methylation
GO:0042135 neurotransmitter catabolic process
GO:0042424 catecholamine catabolic process
GO:0060117 auditory receptor cell development
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078630
View Gene Order
ENSBTAG00000003000
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.317243 Hs.686751
RefSeq NM_001145307 NM_001145308 NM_001145309 NM_001145310 NM_001205138 NM_001271471 NM_145309 XM_006718473
HUGO
OMIM
CCDS CCDS44667 CCDS44668 CCDS55778 CCDS59227 CCDS8208
HPRD 11839
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca