InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GLUD1

Summary

InnateDB Gene

IDBG-631473.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLUD1

Gene Name

Glutamate dehydrogenase 1, mitochondrial

Synonyms

GDH

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007540

Encoded Proteins

IDBP-683029

glutamate dehydrogenase 1, mitochondrial precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148672:
This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:41941042-41979591

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000009923

ENSBTAP00000009923

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004352	glutamate dehydrogenase (NAD+) activity
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0006538	glutamate catabolic process
GO:0006541	glutamine metabolic process
GO:0032024	positive regulation of insulin secretion
GO:0055114	oxidation-reduction process
GO:0072350	tricarboxylic acid metabolic process