Version 5.4
Bos taurus Gene: BT.106544
Summary
InnateDB Gene IDBG-631576.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.106544
Gene Name growth/differentiation factor 2 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005004
Encoded Proteins
IDBP-683122
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:42612012-42616128
Strand Reverse strand
Band
Transcripts
ENSBTAT00000006587 ENSBTAP00000006587
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001525 angiogenesis
GO:0001569 patterning of blood vessels
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0010596 negative regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030308 negative regulation of cell growth
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0032757 positive regulation of interleukin-8 production
GO:0032924 activin receptor signaling pathway
GO:0040007 growth
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048514 blood vessel morphogenesis
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0071773 cellular response to BMP stimulus
GO:2000279 negative regulation of DNA biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
null
View Gene Order
ENSMUSG00000072625
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL E1BBN3
UniProt Splice Variant
Entrez Gene 540384
UniGene Bt.106544
RefSeq NM_001192420
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02062187
GenPept
RNA Seq Atlas 540384

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca