InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FIG4

Summary

InnateDB Gene

IDBG-631597.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FIG4

Gene Name

polyphosphoinositide phosphatase

Synonyms

SAC3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005827

Encoded Proteins

IDBP-683152

polyphosphoinositide phosphatase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112367:
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:40873047-41046003

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000007665

ENSBTAP00000007665

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042578	phosphoric ester hydrolase activity

Biological Process

GO:0007033	vacuole organization
GO:0007626	locomotory behavior
GO:0031642	negative regulation of myelination
GO:0032288	myelin assembly
GO:0043473	pigmentation
GO:0046488	phosphatidylinositol metabolic process
GO:0048666	neuron development