InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SEMA4A

Summary

InnateDB Gene

IDBG-631665.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA4A

Gene Name

semaphorin-4A precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012228

Encoded Proteins

IDBP-683227

semaphorin-4A precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196189:
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:14659269-14679216

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000016223

ENSBTAP00000016223

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0002292	T cell differentiation involved in immune response
GO:0007275	multicellular organismal development
GO:0007409	axonogenesis
GO:0008360	regulation of cell shape
GO:0010594	regulation of endothelial cell migration
GO:0016525	negative regulation of angiogenesis
GO:0045063	T-helper 1 cell differentiation
GO:0071526	semaphorin-plexin signaling pathway