InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP6V1B1

Summary

InnateDB Gene

IDBG-631798.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1B1

Gene Name

V-type proton ATPase subunit B, kidney isoform

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010620

Encoded Proteins

IDBP-683367

V-type proton ATPase subunit B, kidney isoform

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116039:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c\'\', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:13463414-13490532

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014039

ENSBTAP00000014039

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.

Predicted by orthology
Total	70 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Biological Process

GO:0001503	ossification
GO:0006810	transport
GO:0006811	ion transport
GO:0006885	regulation of pH
GO:0007588	excretion
GO:0007605	sensory perception of sound
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0042472	inner ear morphogenesis
GO:0045851	pH reduction
GO:0046034	ATP metabolic process
GO:0055074	calcium ion homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005902	microvillus
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0070062	extracellular vesicular exosome