InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MTM1

Summary

InnateDB Gene

IDBG-631816.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTM1

Gene Name

Myotubularin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014138

Encoded Proteins

IDBP-683389

Myotubularin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171100:
This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:33460693-33551321

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018789

ENSBTAP00000018789

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004438	phosphatidylinositol-3-phosphatase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0019215	intermediate filament binding
GO:0035091	phosphatidylinositol binding
GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0006810	transport
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0044088	regulation of vacuole organization
GO:0045109	intermediate filament organization
GO:0046856	phosphatidylinositol dephosphorylation
GO:0048311	mitochondrion distribution
GO:0070584	mitochondrion morphogenesis

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030175	filopodium
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome