Version 5.4
Bos taurus Gene: GABRA3
Summary
InnateDB Gene IDBG-631941.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRA3
Gene Name gamma-aminobutyric acid receptor subunit alpha-3 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006691
Encoded Proteins
IDBP-683520
gamma-aminobutyric acid receptor subunit alpha-3 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011677:
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:34852875-35094442
Strand Reverse strand
Band
Transcripts
ENSBTAT00000008798 ENSBTAP00000008798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005216 ion channel activity
GO:0005230 extracellular ligand-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034220 ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000011677
View Gene Order
ENSMUSG00000031343
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_24987
GABA A receptor activation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_198560
GABA A receptor activation pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_268398
Orphan transporters pathway
REACT_198558
Ligand-gated ion channel transport pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_224131
GABA receptor activation pathway
REACT_259290
Neuronal System pathway
REACT_233318
Transmission across Chemical Synapses pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.175
RefSeq NM_174542
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca