InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KIFAP3

Summary

InnateDB Gene

IDBG-632045.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIFAP3

Gene Name

kinesin-associated protein 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017727

Encoded Proteins

IDBP-683641

kinesin-associated protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075945:
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 \'Armadillo\' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:38360035-38502334

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023574

ENSBTAP00000023574

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0019894	kinesin binding

Biological Process

GO:0007017	microtubule-based process
GO:0008104	protein localization
GO:0008285	negative regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0046587	positive regulation of calcium-dependent cell-cell adhesion

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005813	centrosome
GO:0005871	kinesin complex
GO:0005876	spindle microtubule
GO:0015630	microtubule cytoskeleton
GO:0016939	kinesin II complex
GO:0030990	intraciliary transport particle
GO:0070062	extracellular vesicular exosome