InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PRKD1

Summary

InnateDB Gene

IDBG-632158.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKD1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012789

Encoded Proteins

IDBP-683807

protein kinase D1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184304:
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:40528795-40682810

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000016995

ENSBTAP00000016995

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006468	protein phosphorylation
GO:0007030	Golgi organization
GO:0010595	positive regulation of endothelial cell migration
GO:0010837	regulation of keratinocyte proliferation
GO:0010976	positive regulation of neuron projection development
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0032793	positive regulation of CREB transcription factor activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034599	cellular response to oxidative stress
GO:0035556	intracellular signal transduction
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045669	positive regulation of osteoblast differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048193	Golgi vesicle transport
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060548	negative regulation of cell death
GO:1901727	positive regulation of histone deacetylase activity
GO:2001028	positive regulation of endothelial cell chemotaxis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005938	cell cortex